Dear ABCA Subscribers,
The journal Food and Chemical Toxicology today announced the retraction of the article Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize by Séralini et al first published online in September 2012.
Shortly after the article was originally published, the journal received many letters to the editor expressing concerns about the validity of the findings, the proper use of animals and even allegations of fraud.
The study alleged that biotech corn and herbicides caused tumours and organ damage, and led to premature death in laboratory rats.
Food Standards Australia New Zealand (FSANZ), in agreement with food safety regulators globally, rejected the conclusions of the study, finding “On the basis of the many scientific deficiencies identified in the study, FSANZ does not accept the conclusions made by the authors and has therefore found no justification to reconsider the safety of NK603 corn.”
The journal Food and Chemical Toxicology’s retraction today states:
"The Editor-in-Chief found no evidence of fraud or intentional misrepresentation of the data. However, there is a legitimate cause for concern regarding both the number of animals in each study group and the particular strain selected. The low number of animals had been identified as a cause for concern during the initial review process, but the peer-review decision ultimately weighed that the work still had merit despite this limitation. A more in-depth look at the raw data revealed that no definitive conclusions can be reached with this small sample size regarding the role of either NK603 or glyphosate in regards to overall mortality or tumor incidence. Given the known high incidence of tumors in the Sprague-Dawley rat, normal variability cannot be excluded as the cause of the higher mortality and incidence observed in the treated groups."
The journal’s letter to Séralini requesting he withdraw his article can be downloaded here. The responses of a number of Australian and international scientists given when the study was first published can be found here.
ABCA will be disseminating this information in the coming weeks and months to ensure that Australians are informed of the erroneous nature of the conclusions drawn from this study. We would encourage subscribers to do the same.
Jessica Lee
Chair, Public Affairs Working Group
Agricultural Biotechnology Council of Australia
GMO kooks are like AGW kooks, fabricating and abusing study after study to sell their particular fear.
I kept waiting for the other shoe to drop, but that has not happened yet. From the article:
"Given the known high incidence of tumors in the Sprague-Dawley rat, normal variability cannot be excluded as the cause of the higher mortality and incidence observed in the treated groups.”
I'm assuming that there was a control group. Let's look at two boundary conditions.
1. Suppose that the researchers had used a strain of rats that never get cancer when properly cared for. If the carcinogenicity of Roundup plus frankenfood is small, there would have been nothing to report. (On the other hand, if cancer did show up in the ultra-low cancer strain, that would have been interesting.)
2. Suppose that the researchers had used a strain of rats that always get cancer -- even when properly cared for. I don't know if such a strain of rats exists. (However Flat Coat Retrievers, a medium-large dog breed, typically die from cancer before the age of 10 when they're well cared for.) In this case, there would have been no difference in cancer rates between the experimental and control groups. Both would have been 100%.
Suppose that the researchers wanted to optimimize the sensitivity of rat carcinogenicity measurement in their study. Then they would have chosen a strain that ordinarily gets cancer more than 0% of the time, and less than 100% of the time. 50% would have been a good choice. In light of these a priori considerations, criticizing the Séralini study for its use of Sprague-Dawley rats is NOT reasonable.
However the small sample size criticism is reasonable.
Interesting read, one question I have, we know the harmful effects of lead there is no doubt.
They knew about it a thousand years ago (adulteration of wine to make it taste better?) but how do we know it causes violence?
On the face of it the study is spot on but!
To me it's like citing a deprived childhood as an excuse for antisocial behavior.
There are a thousand times more people with the same background who don't offend.
Just a wondering
Kuhnkat,
Here's that lead-violent crime article that I mentioned earlier. I do not see this as being similar to that retracted frankenfood article. If there is a Pb threshold, it's so low that we cannot presently measure it.
I thought that the author did a good job. He even included dose-response data, as well as more sensitive D-R proxy data. If you have contrary evidence, or if you can find a flaw in his logic, I'm all ears!
America's Real Criminal Element: Lead
"New research finds Pb is the hidden villain behind violent crime, lower IQs, and even the ADHD epidemic. And fixing the problem is a lot cheaper than doing nothing."
—By Kevin Drum
January/February 2013 Issue
http://www.motherjones.com/environment/2013/01/lead-crime-link-gasoline
Marc,
It's fashionable to claim a 'conspiracy' rather than recognise 'incompetence'.
Perhaps you could supply some evidence that Monsanto has been involved in some sort of underhanded manner re this particular retraction?
I smell a rat, or perhaps it is a Monsanto research consultancy!
Comment from: kuhnkat December 1st, 2013 at 1:32 pm
"I believe the studies reported in Mother Jones may actually have more of a problem ignoring possible confounding factors. Again, just because there is a correlation does NOT mean there is a physical connection. The seemingly strong evidence reported was NOT shown to be directly connected to the lead as issues such as diet in general, living in a generally unhealthy environment, possible genetic effects, poor social environment, etc. were all ignored."
It would be more sporting for me to rely on my aging memory than to redo old homework. That said . . .
The trend in decreased violent crime is in several developed countries that have taken tetraethyl lead out of their petrol. If it was just the USA, one of the confounding factors would have been the Freakonomics Effect, because of the Roe v Wade decision on abortion in 1973.
Of course, some countries, like the UK, insist on shooting themselves in the foot, with draconian gun control laws, which actually increase violent crime. A better criminology 'laboratory' would have been a world in which no country, state, province, or city made any changes whatsoever in their firearms laws for the last half-century. But fortunately for us, humans are not laboratory rats.
Another possible confounding factor is income inequality, which in the USA at least, has been getting worse over time. Ceterus parabus (spelling?), one would expect this to increase -- rather than decrease -- violent crime rates over time.
Although the Lead-Violent Crime Hypothesis is not yet a conversation-stopper, we can take cold comfort in the fact that it's on a stronger evidentiary footing than the CAGW Hypothesis. Statistical associations trump hallucinations and data-diddling any day of the week. 🙂
Larry,
If you look into the data and procedures in those Lead studies you will find the same flaws we are discussing. The amount of paint a child would have to eat to have the negative effects reported amounts to more than one building denuded...
I believe the studies reported in Mother Jones may actually have more of a problem ignoring possible confounding factors. Again, just because there is a correlation does NOT mean there is a physical connection. The seemingly strong evidence reported was NOT shown to be directly connected to the lead as issues such as diet in general, living in a generally unhealthy environment, possible genetic effects, poor social environment, etc. were all ignored.
Debbie et al.
A good recent example of overdosing and more, and then the rebuttal being ignored is my recent paper:
Abbot J., Marohasy J. 2011. Has the herbicide Diuron caused mangrove dieback? A re-examination of the evidence. Human and Ecological Risk Assessment. Volume 17, Pages 1077-1094. http://www.tandfonline.com/doi/abs/10.1080/10807039.2011.605672
Put in context here: https://climatelab.com.au/saving-the-great-barrier-reef/